A curcumin-based TPA four-branched copper(II) complex probe for in vivo early tumor detection
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Authors: Pi, Zongxin; Wang, Jiafeng; Jiang, Bo; Cheng, Gang; Zhou, Shuangsheng
Abstract
A multibranched Cu(II) complex CuL2 curcumin-based was synthesized and characterized by single-crystal X-ray diffraction analysis. The photophysical properties of the complex have been investigated both experimentally and theoretically. The results show that the target complex exhibits higher quantum yield and larger two-photon absorption (TPA) cross-section in the near infrared (NIR) region compared with its free ligand. The cell imaging studies in vitro and in vivo reveal that the complex shows good photostability and excellent tumor targeting capability to tested cancerous cells, which can be potentially used for early tumor detection. (C) 2014 Elsevier B.V. All rights reserved.
DNA Binding, DNA Cleavage, and Cellular Imaging of a Copper(II) Complex Based on Curcumin
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
Authors: Si, G. F.; Jiang, B.; Wei, D.; Wang, J. F.; Zhou, S. S.
Abstract
Binding property between CT-DNA and a Cu(II) complex, namely CuL2, where HL = 1,7-bis(4-butoxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione, was determined by UV-Vis absorption, fluorescence spectroscopy, and viscosity measurements. The results showed that the binding of the complex with CT-DNA was through the intercalative mode and the binding constant (K-b) value was found to be 3.82 x 10(4) M. DNA cleavage studies showed that CuL2 exhibited effective cleavage activity on pBR322 plasmid DNA in absence of external agents. Additionally, cellular imaging studies also indicated that CuL2 has a higher toxicity to MCF-7 cell lines compared with its corresponding ligand HL.
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