Anti-CTTN monoclonal antibody, clone 502DU9.7.4

Antibody Isotype

IgM

Clone

502DU9.7.4

Species Reactivity

Human

Conjugate

Application Notes

WB: 1:1000-8000

Alternative Names

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

Entrez Gene ID

UniProt ID

Antigen Description

This gene is overexpressed in breast cancer and squamouscell carcinomas of the head and neck. The encoded protein islocalized in the cytoplasm and in areas of the cell-substratumcontacts. This gene has two roles:regulating the interactionsbetween components of adherens-type junctions andorganizingthe cytoskeleton and cell adhesion structures of epithelia andcarcinoma cells. During apoptosis, the encoded protein is degradedin a caspase-dependent manner. The aberrant regulation of this genecontributes to tumor cell invasion and metastasis. Three splicevariants that encode different isoforms have been identified forthis gene.

Pathway

Bacterial invasion of epithelial cells; E-cadherin signaling in the nascent adherens junction; FGF signaling pathway; N-cadherin signaling events; Pathogenic Escherichia coli infection; Proteoglycans in cancer; Shigellosis; Syndecan-3-mediated signaling events;