A synthetic peptide of human CTDSPL is used for rabbit immunization.
Conjugate
Unconjugated
Target
Alternative Names
CTDSPL; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; C3orf8, chromosome 3 open reading frame 8; CTD small phosphatase-like protein; HYA22; HYA22 protein; PSR1; RB protein serine phosphatase from chromosome 3; RBS
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
Pathway
BMP receptor signaling, organism-specific biosystem; Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem.
Citations
Publication ()
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COA
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