Anti-CSRNP1 polyclonal antibody (DPAB-DC2856)

Mouse anti-Human CSRNP1 (full length) polyclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Mouse
Species Reactivity
Human
Immunogen
AXUD1 (AAH38949, 1 a.a. ~ 589 a.a) full-length recombinant protein with GST tag. The sequence is MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWDSEEEGPWDQMPLPDRDFCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTSVPSRGGCTLGMALRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAGVPQAEAGLPPVVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRRIDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCENPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPLAKPPMNNELGDNSCSSDMTDSSTASSSASGTSEAPDCPTHPGLPGPGFQPGVDDDSLARILSFSDSDFG
Conjugate
Unconjugated

Target


Alternative Names
CSRNP1; cysteine-serine-rich nuclear protein 1; AXUD1; URAX1; TAIP-3; CSRNP-1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CSRNP1 (Cysteine And Serine Rich Nuclear Protein 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. An important paralog of this gene is CSRNP2. This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants.
Antigen Description
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Binds to the consensus sequence 5-AGAGTG-3 and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis. The function about CSRNP1 antigen include RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; molecular_function; sequence-specific DNA binding; sequence-specific DNA binding transcription.

Citations


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References


Ze, YG; Hu, RP; et al. Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 102:470-478(2014).
Gingras, S; Pelletier, S; et al. Characterization of a Family of Novel Cysteine- Serine-Rich Nuclear Proteins (CSRNP). PLOS ONE 2:-(2007).

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