Anti-CSNK1G2 monoclonal antibody, clone 2B0

Antibody Isotype

IgG1

Clone

2B0

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to Human Casein Kinase 1 gamma 2 aa 163-415 (C terminal). Produced in E.coli.Sequence: YRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSL TGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKE RYQKIGDTKRATPIEVLCENFPEEMATYLRY

Conjugate

Application Notes

WB: 1/2000;

Alternative Names

CSNK1G2; casein kinase 1, gamma 2; casein kinase I isoform gamma-2; CK1g2; CKI-gamma 2; casein kinase 1 isoform gamma-2;

Entrez Gene ID

UniProt ID

Antigen Description

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.

Pathway

FoxO family signaling, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Sphingolipid de novo biosynthesis, organism-specific biosystem.