The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity.
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Pregel, MJ; Shen, SH; et al. Regulation of protein tyrosine phosphatase 1C: Opposing effects of the two src homology 2 domains. PROTEIN ENGINEERING 8:1309-1316(1995).
Werkema, EL; Castro, L; et al. Selectivity in the C-H Activation Reaction of CH3OSO2CH3 with [1,2,4-(Me3C)(3)C5H2](2)CeH or [1,2,4-(Me3C)(3)C5H2][1,2-(Me3C)(2)-4-(Me2CCH2)C5H2]Ce: To Choose or Not To Choose. ORGANOMETALLICS 31:870-881(2012).
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