Anti-CRB2 (aa 1255-1285) polyclonal antibody

The mechanisms that localise 53BP1 to sites of DNA double-strand breaks (DSBs) have remained elusive, despite this protein's key roles in DNA damage response signalling and repair processes. Recent studies, including the work by Mallette et al (2012) in this issue of The EMBO Journal, now provide crucial insights into the roles of ubiquitin-dependent signalling cascades at DNA damage sites required for chromatin-mediated 53BP1 recruitment.

Ceramic matrix composites (CMCs) with predominant concentration of TiB2 have recently become the focus of intensive studies due to their potential application in the nuclear industry and other high temperature devices. Thus, in this study, composites consisting of borides fabricated "in situ" (in the one stage process from elemental powders) have been investigated. Self-propagating high temperature synthesis (SHS) combined with pseudo-hot isostatic pressing (p-HIP) was used to utilize the heat of highly exothermic reaction related to the synthesis of TiB2 with NbB2 or CrB2, respectively, for densification. The intended volume fraction of TiB2 was 70% in both cases. The XRD patterns revealed that TiB2 was a predominant phase of each composite while the second ceramic phase was NbTiB4 or (Cr0.5Ti0.5)B-2, solid solution respectively. No unreacted elements were detected. The composite in Ti-Cr-B system exhibited better homogeneity and higher relative density. The Vickers hardness of 20.83+/-0.26 GPa for this composite was also higher than that of 16.67+/-0.28 GPa for the composite containing Nb. Therefore, the SHS process can be seen as being applicable for the fabrication of "in situ" CMCs, thanks to the liquid phase during densification.