Anti-CRB1 (aa 26-134) polyclonal antibody

Species Reactivity

Human

Immunogen

CRB1 (NP_036208, 26 a.a. ~ 134 a.a) partial recombinant protein with GST tag. The sequence is FCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATC VNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVC

Conjugate

Alternative Names

CRB1; crumbs family member 1, photoreceptor morphogenesis associated; LCA8; RP12; protein crumbs homolog 1;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]

Pathway

Hippo signaling pathway.