CPSF3 (NP_057291, 585 a.a. ~ 684 a.a) partial recombinant protein with GST tag. The sequence is LEVQSNPKIRKGAVQKVSKKLEMHVYSKRLEIMLQDIFGEDCVSVKDDSILSVTVDGKTA NLNLETRTVECEEGSEDDESLREMVELAAQRLYEALTPVH
Conjugate
Unconjugated
Target
Alternative Names
CPSF3; cleavage and polyadenylation specific factor 3, 73kDa; CPSF73; CPSF-73; cleavage and polyadenylation specificity factor subunit 3; mRNA 3-end-processing endonuclease CPSF-73;
This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3-end pre-mRNA processing.
Pathway
Cleavage of Growing Transcript in the Termination Region; Processing of Capped Intron-Containing Pre-mRNA; Processing of Intronless Pre-mRNAs; RNA Polymerase II Transcription Termination
Citations
Publication ()
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