A synthetic peptide of human CP110 is used for rabbit immunization.
Conjugate
Unconjugated
Target
Alternative Names
CCP110; centriolar coiled coil protein 110kDa; CP110; Cep110; centriolar coiled-coil protein of 110 kDa; centrosomal protein CP110; centrosomal protein of 110 kDa;
CCP110 (centriolar coiled coil protein 110kDa) is a protein-coding gene. Diseases associated with CCP110 include protein s deficiency, and prostatitis, and among its related super-pathways are G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include protein binding. Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
Pathway
Cell Cycle; Cell Cycle, Mitotic; Centrosome maturation; G2/M Transition; Loss of Nlp from mitotic centrosomes; Loss of proteins required for interphase microtubule organization??from the centrosome; Mitotic G2-G2/M phases; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition;
Citations
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