Anti-COLEC12 monoclonal antibody

Antibody Isotype

IgG2a

Species Reactivity

Human

Immunogen

Recombinant fragment: AISTNSELST FRSDILDLRQ QLREITEKTS KNKDTLEKLQ ASGDALVDRQ SQLKETLENN SFLITTVNKT LQAYNGYVTN LQQDTSVLQG NLQNQMYSHN, corresponding to amino acids 101-200 of Human Colec12 (AAH60789) with a proprietory tag.

Conjugate

Alternative Names

COLEC12; collectin sub-family member 12; collectin-12; CL P1; SCARA4; SRCL; hCL-P1; collectin placenta protein 1; nurse cell scavenger receptor 2; scavenger receptor class A, member 4; scavenger receptor with C-type lectin; CLP1; NSR2;

Entrez Gene ID

UniProt ID

Antigen Description

Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.

Pathway

Phagosome, organism-specific biosystem; Phagosome, conserved biosystem;