Anti-COLEC11 monoclonal antibody (DCABH-11088) Made to order

Rabbit anti-Human COLEC11 monoclonal antibody for WB, ELISA

View other COLEC11 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human COLEC11 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
COLEC11; collectin sub-family member 11; MGC3279
Entrez Gene ID

Product Background


Gene summary
COLEC11 (Collectin Subfamily Member 11) is a Protein Coding gene. Diseases associated with COLEC11 include 3mc syndrome 2 and 3mc syndrome. Among its related pathways are Immune System and Phagosome. GO annotations related to this gene include mannose binding. An important paralog of this gene is MBL2. This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Antigen Description
COLEC11 is a member of the collectin family of C-type lectins, which contain a collagen-like domain and a carbohydrate recognition domain, and play a role in host-defense (Keshi et al. , 2006 [PubMed 17179669]). 3MC syndrome 2 (3MC2) [MIM:265050]: A disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Note=The disease is caused by mutations affecting the gene represented in this entry.

Citations


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References


Yoshizaki, T; Ohtani, K; et al. Comparison of human blood concentrations of collectin kidney 1 and mannan-binding lectin. JOURNAL OF BIOCHEMISTRY 151:57-64(2012).

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