Anti-COL4A4 (internal region) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to internal of human COL4A4.

Conjugate

Application Notes

IHC: 1:50-1:100; IF: 1:100-1:500. ELISA: 1:1000. & The optimal working dilution should be determined by the end user.

Alternative Names

COL4A4; collagen, type IV, alpha 4; CA44; collagen alpha-4(IV) chain; Collagen IV, alpha-4 polypeptide; collagen of basement membrane, alpha-4 chain;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3 UTR.

Pathway

Amoebiasis; Axon guidance; Collagen formation; ECM-receptor interaction.