Anti-COL1A2 (aa 1044-1093) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide corresponding to a region within internal amino acids 1044 - 1093 (PGSVGPAGPR GPAGPSGPAG KDGRTGHPGT VGPAGIRGPQ GHQGPAGPPG) of Human COL1A2 (NP_000080)

Conjugate

Application Notes

WB: 1 μg/ml.

Alternative Names

COL1A2; collagen, type I, alpha 2; OI4, osteogenesis imperfecta type IV; collagen alpha-2(I) chain; alpha 2(I) collagen; alpha 2 collagen type I; collagen I; alpha 2 polypeptide; collagen of skin; tendon and bone; alpha 2 chain; type I procollagen; alpha

Entrez Gene ID

UniProt ID

Antigen Description

COL1A2 is the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Defects in COL1A2 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.

Pathway

Amoebiasis; Axon guidance; C-MYB transcription factor network; Cell surface interactions at the vascular wall; Developmental Biology; ECM-receptor interaction.