Anti-COASY (aa 461-564) polyclonal antibody

Species Reactivity

Human

Immunogen

COASY (NP_079509, 461 a.a. ~ 564 a.a) partial recombinant protein with GST tag. The sequence is AEGKRVCVIDAAVLLEAGWQNLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMS GQQLVEQSHVVLSTLWEPHITQRQVEKAWALLQKRIPKTHQALD

Conjugate

Alternative Names

COASY; CoA synthase; NBP; DPCK; PPAT; UKR1; NBIA6; pOV-2; bifunctional coenzyme A synthase; nucleotide binding protein; phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase; bifunctional phosphopantetheine adenylyl transferase/dephospho CoA

Entrez Gene ID

UniProt ID

Antigen Description

Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms.

Pathway

Coenzyme A biosynthesis; CoA; CoA; Defective BTD causes biotidinase deficiency