Rabbit Anti-Human CNN2 Polyclonal antibody

This paper presents a novel adaptively connected neural network (ACNet) to improve the traditional convolutional neural networks (CNNs) in two aspects. First, ACNet employs a flexible way to switch global and local inference in processing the internal feature representations by adaptively determining the connection status among the feature nodes (e.g., pixels of the feature maps)(1). We can show that existing CNNs, the classical multilayer perceptron (MLP), and the recently proposed non-local network (NLN) [48] are all special cases of ACNet. Second, ACNet is also capable of handling non-Euclidean data. Extensive experimental analyses on a variety of benchmarks (i.e., ImageNet-1k classification, COCO 2017 detection and segmentation, CUHK03 person re-identification, CIFAR analysis, and Cora document categorization) demonstrate that ACNet cannot only achieve state-of-the-art performance but also overcome the limitation of the conventional MLP and CNN2. The code is available at https: //github.com/wanggrun/Adaptively-Connected-Neural-Networks.

Calponin is an actin cytoskeleton-associated protein that regulates motility-based cellular functions. Three isoforms of calponin are present in vertebrates, among which calponin 2 encoded by the Cnn2 gene is expressed in multiple types of cells, including blood cells from the myeloid lineage. Our previous studies demonstrated that macrophages from Cnn2 knockout (KO) mice exhibit increased migration and phagocytosis. Intrigued by an observation that monocytes and macrophages from patients with rheumatoid arthritis had increased calponin 2, we investigated anti-glucose-6-phosphate isomerase serum-induced arthritis in Cnn2-KO mice for the effect of calponin 2 deletion on the pathogenesis and pathology of inflammatory arthritis. The results showed that the development of arthritis was attenuated in systemic Cnn2-KO mice with significantly reduced inflammation and bone erosion than that in age-and stain background-matched C57BL/6 wild-type mice. In vitro differentiation of calponin 2-null mouse bone marrow cells produced fewer osteoclasts with decreased bone resorption. The attenuation of inflammatory arthritis was confirmed in conditional myeloid cell-specific Cnn2-KO mice. The increased phagocytotic activity of calponin 2-null macrophages may facilitate the clearance of autoimmune complexes and the resolution of inflammation, whereas the decreased substrate adhesion may reduce osteoclastogenesis and bone resorption. The data suggest that calponin 2 regulation of cytoskeleton function plays a novel role in the pathogenesis of inflammatory arthritis, implicating a potentially therapeutic target.