General Notes
This product (Catalog No. DPABH-22726) is a rabbit-derived polyclonal antibody raised against human CLUH, targeting the amino acid region 1120–1309 of the protein. This antibody exhibits cross-reactivity with Human CLUH from mouse and monkey. It has been affinity purified by Protein A. Clustered mitochondria homolog (CLUH) is a conserved RNA-binding protein, that binds transcripts encoding proteins involved in the respiratory chain, the tricarboxylic acid (TCA) cycle, and other mitochondrial metabolic pathways. Upon loss of CLUH, target mRNAs are subjected to faster decay, and their respective proteins are decreased in abundance. This leads to alterations in mitochondrial distribution (mitochondrial clustering as the gene name alludes to) mitochondrial cristae integrity, respiratory defects, loss of mtDNA, and decreased activity of TCA cycle enzymes. (PMID: 35559794).
DPABH-22726 is suitable for use in Western blot (WB) (1:1,000–1:4,000), IHC (1:250–1:1,000), IF/ICC (1:200–1:800) applications.
DPABH-22726 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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