Anti-CLDN10 monoclonal antibody (DCABH-11036) Made to order

Rabbit anti-Human CLDN10 monoclonal antibody for WB, ELISA

View other CLDN10 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CLDN10 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CLDN10; claudin 10; claudin-10; CPETRL3; OSP L; OSP-like protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CLDN10 (Claudin 10) is a Protein Coding gene. Diseases associated with CLDN10 include hepatocellular carcinoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN18. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.
Antigen Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Multiple transcript variants encoding different isoforms have been found for this gene. Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henles loop in kidney. Claudin-10 is a protein that in humans is encoded by the CLDN10 gene. It belongs to the group of claudins. 0The function about CLDN10 antigen include identical protein binding; structural molecule activity.
Pathway
Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Nakatsukasa, M; Kawasaki, S; et al. Tumor-Associated Calcium Signal Transducer 2 Is Required for the Proper Subcellular Localization of Claudin 1 and 7 Implications in the Pathogenesis of Gelatinous Drop-Like Corneal Dystrophy. AMERICAN JOURNAL OF PATHOLOGY 177:1344-1355(2010).
Blanchard, AAA; Watson, PH; et al. Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouse. DNA AND CELL BIOLOGY 25:79-86(2006).

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