Anti-CKMT1B (aa 327-417) polyclonal antibody

Species Reactivity

Human

Immunogen

CKMT1B (NP_066270, 327 a.a. ~ 417 a.a) partial recombinant protein with GST tag. The sequence is GVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGGVFDISNLDRLGKSEVELVQLV IDGVNYLIDCERRLERGQDIRIPTPVIHTKH

Conjugate

Alternative Names

CKMT1B; creatine kinase, mitochondrial 1B; CKMT; CKMT1; UMTCK; creatine kinase U-type, mitochondrial; U-MtCK; mia-CK; ubiquitous mitochondrial creatine kinase; acidic-type mitochondrial creatine kinase; creatine kinase, mitochondrial 1 (ubiquitous);

Entrez Gene ID

UniProt ID

Antigen Description

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Pathway

Arginine and proline metabolism; Creatine metabolism; Creatine pathway; Metabolism of amino acids and derivatives