Anti-CKMT1A polyclonal antibody (DPAB-DC2367)

Rabbit anti-Human CKMT1A (N-terminal) polyclonal antibody for WB, ELISA Datasheet

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Specifications


Host Species
Rabbit
Species Reactivity
Human, Mouse
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CKMT1A.
Conjugate
Unconjugated

Applications


Application Notes
ELISA: 1:1000; WB: 1:100-500. & The optimal working dilution should be determined by the end user.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CKMT1A; creatine kinase, mitochondrial 1A; CKMT1; creatine kinase U-type, mitochondrial; U-MtCK; mia-CK
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CKMT1A (Creatine Kinase, Mitochondrial 1A) is a Protein Coding gene. Diseases associated with CKMT1A include prostate rhabdomyosarcoma and dresslers syndrome. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and creatine kinase activity. An important paralog of this gene is CKMT1B. Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
Antigen Description
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e. g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. The function about CKMT1A antigen include ATP binding; creatine kinase activity.
Pathway
Arginine and proline metabolism; Creatine metabolism; Creatine pathway; Metabolism of amino acids and derivatives.

Citations


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References


Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).

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