Rabbit Anti-Human CHRNG Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

A synthesized peptide derived from human CHRNG

Conjugate

Application Notes

WB: 1:1000-3000

General Notes

This product (Catalog No. DPABH-24617) is a rabbit-derived polyclonal antibody raised against human CHRNG. This antibody exhibits cross-reactivity with CHRNG from mouse and rat. It has been affinity purified by Protein A. The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
DPABH-24617 is suitable for use in Western blot (WB) (1:1,000–1:3,000) application.
DPABH-24617 is supplied as a liquid formulation in PBS containing 50% glycerol, and 0.02% sodium azide. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CHRNG, ACHRG, Acrg

Entrez Gene ID

UniProt ID