Specifications
Immunogen
Synthetic peptide: SRHVKKEHFISQ, corresponding to internal sequence amino acids 403-414 of Human Nicotinic Acetylcholine Receptor beta 3
Applications
Application Notes
Peptide Antibody detection limit dilution 1/16,000. WB: Use at a concentration of 1 - 3 μg/ml. Detects a band of approximately 51 kDa (predicted molecular weight: 51 kDa).
Target
Alternative Names
CHRNB3; cholinergic receptor, nicotinic, beta 3 (neuronal); neuronal acetylcholine receptor subunit beta-3; cholinergic receptor, nicotinic, beta polypeptide 3; acetylcholine receptor, nicotinic, beta 3 (neuronal); acetylcholine receptor, neuronal nicotin
Product Background
Antigen Description
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. The subunits that make up the muscle and neuronal forms of nAChRs are encoded by separate genes and have different primary structure. There are several subtypes of neuronal nAChRs that vary based on which homologous subunits are arranged around the central channel. They are classified as alpha-subunits if, like muscle alpha-1, they have a pair of adjacent cysteines as part of the presumed acetylcholine binding site. Subunits lacking these cysteine residues are classified as beta-subunits.
Pathway
Acetylcholine Binding And Downstream Events; Highly calcium permeable nicotinic acetylcholine receptors; Neuroactive ligand-receptor interaction; Neuronal System
Citations
Publication ()
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COA
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