A region within synthetic peptide: TEIDLVLKSE VASLDDFTPS GEWDIVALPG RRNENPDDST YVDITYDFII, corresponding to internal sequence amino acids 181-230 of Human Nicotinic Acetylcholine Receptor beta 2
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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