Anti-CHRNA2 (aa 27-136) polyclonal antibody

Species Reactivity

Human

Immunogen

CHRNA2 (NP_000733, 27 a.a. ~ 136 a.a) partial recombinant protein with GST tag. The sequence is EEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRLFKHLFRGYNRWARPVPNTSDVVIV RFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPADFGNITSLRVP

Conjugate

Alternative Names

CHRNA2; cholinergic receptor, nicotinic, alpha 2 (neuronal); neuronal acetylcholine receptor subunit alpha-2; acetylcholine receptor, nicotinic, alpha 2 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal);

Entrez Gene ID

UniProt ID

Antigen Description

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Pathway

Acetylcholine Binding And Downstream Events; Highly calcium permeable nicotinic acetylcholine receptors; Neuroactive ligand-receptor interaction; Neuronal System.