Specifications
Immunogen
A synthetic peptide of human CHRM4 is used for rabbit immunization.
Target
Alternative Names
CHRM4; cholinergic receptor, muscarinic 4; muscarinic acetylcholine receptor M4; acetylcholine receptor; muscarinic 4; acetylcholine receptor, muscarinic 4; HM4; M4R;
Product Background
Antigen Description
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition.
Pathway
Amine ligand-binding receptors, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem.
Citations
Publication ()
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COA
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