Anti-CHRFAM7A polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to human CHRFAM7A. The sequence is QKYCIYQHFQFQ

Conjugate

Application Notes

ELISA: 1:1000. & The optimal working dilution should be determined by the end user.

Alternative Names

CHRFAM7A; CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion; D-10; CHRNA7; CHRNA7-DR1; CHRNA7-FAM7A fusion protein; alpha-7 nicotinic cholinergic receptor subunit; alpha 7 neuron

Entrez Gene ID

UniProt ID

Antigen Description

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

Pathway

Acetylcholine Binding And Downstream Events; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors; Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell; SIDS Susceptibility Pathways