CHD4 (NP_001264, 1632 a.a. ~ 1730 a.a) partial recombinant protein with GST tag. The sequence is ETEPKGAADVEKVEEKSAIDLTPIVVEDKEEKKEEEEKKEVMLQNGETPKDLNDEKQKKN IKQRFMFNIADGGFTELHSLWQNEERAATVTKKTYEIWH
Conjugate
Unconjugated
Target
Alternative Names
CHD4; chromodomain helicase DNA binding protein 4; CHD-4; Mi-2b; Mi2-BETA; chromodomain-helicase-DNA-binding protein 4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein;
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms.
Pathway
Gene Expression; RNA Polymerase I Transcription; RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription; Viral carcinogenesis
Citations
Publication ()
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