Mouse anti-Human CHD3 polyclonal antibody

Species Reactivity

Human

Immunogen

CHD3 (NP_001005273, 1654 a.a. ~ 1741 a.a) partial recombinant protein with GST tag. The sequence is KPLDGQEHRERPEGETGDLGKREDVKGDRELRPGPRDEPRSNGRREEKTEKPRFMFNIAD GGFTELHTLWQNEERAAISSGKLNEIWH

Conjugate

Alternative Names

CHD3; chromodomain helicase DNA binding protein 3; ZFH; Mi-2a; Mi2-ALPHA; chromodomain-helicase-DNA-binding protein 3; hZFH; CHD-3; zinc finger helicase; ATP-dependent helicase CHD3; mi-2 autoantigen 240 kDa protein; zinc-finger helicase (Snf2-like);

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.

Pathway

Gene Expression; RNA Polymerase I Transcription; RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription;