Anti-CHD2 monoclonal antibody (DCABH-10994) Made to order

Rabbit anti-Human CHD2 monoclonal antibody for WB, ELISA

View other CHD2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CHD2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CHD2; chromodomain helicase DNA binding protein 2; chromodomain-helicase-DNA-binding protein 2; DKFZp547I1315; DKFZp686E01200; DKFZp781D1727
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CHD2 (Chromodomain Helicase DNA Binding Protein 2) is a Protein Coding gene. Diseases associated with CHD2 include epileptic encephalopathy, childhood-onset and myoclonic-astastic epilepsy. GO annotations related to this gene include poly(A) RNA binding and core promoter sequence-specific DNA binding. An important paralog of this gene is CHD3. The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Antigen Description
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Epileptic encephalopathy, childhood-onset (EEOC) [MIM:615369]: A severe form of epilepsy characterized by onset of multiple seizure types in the first few years of life and associated with poor prognosis. Affected individuals have cognitive regression and intellectual disability. Note=The disease is caused by mutations affecting the gene represented in this entry. Chromodomain-helicase-DNA-binding protein 2 is an enzyme that in humans is encoded by the CHD2 gene. CHD2 catalyzes the assembly of chromatin into periodic arrays; and the N-terminal region of CHD2, which contains tandem chromodomains, serves an auto-inhibitory role in both the DNA-binding and ATPase activities of CHD2. The function about CHD2 antigen include ATP binding; ATP-dependent DNA helicase activity; DNA binding; helicase activity; hydrolase activity; nucleotide binding.

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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Harada, A; Yoshimura, S; et al. Generation of a Rat Monoclonal Antibody Specific for Chd2. HYBRIDOMA 29:173-177(2010).
Ohkawa, Y; et al. Monoclonal Antibodies 6D2 and 8H3 Against Mouse Chd2. HYBRIDOMA 29:270-270(2010).

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