Anti-CFI monoclonal antibody, clone 3R/8

Introduction Anxiety and depression are significant concerns in breast cancer patients, and it may remain for a long term after primary treatments. The hospital anxiety and depression scale (HADS) is widely used to measure depressive and anxiety symptoms in clinical practices. The purpose of this study was to assess the psychometric properties of the Persian version of this scale in Iranian breast cancer survivors. Methods A total of 305 patients with breast cancer, refered to Cancer Hospital in northen Iran and completed the primary treatments were enrolled in. All patients responded to a 14-item HADS. We performed confirmatory factor analysis (CFA) to examine the factor structure of HADS and the item-scale analysis in order to estimate the item reliability and consider the Cronbach's alpha as a measure of internal consistency. Results With a threshold of >= 8, the prevalence of anxiety and depression symptoms (moderate/severe) was 78.9 and 66.9%, respectively. The Cronbach's alpha coefficients for anxiety and depression were 0.81 and 0.78, respectively. The CFA confirmed the two-factor structure model for HADS, indicating a good fitting summary indexes (chi 2/df = 2.83, NFI = 0.88, RFI = 0.82, IFI = 0.92, CFI = 0.92, and RMSEA = 0.078). Conclusion The CFA and item reliability analysis have indicated an excellent psychometric property of the Persian version of HADS to measure depressive and anxiety symptoms in breast cancer survivors. Thus, HADS is a useful screening tool to identify post-breast cancer anxiety and depressive disorders.

Background: Childhood abuse and neglect have been associated with long term psychological consequences. There is no valid, reliable and gender invariant scale available for the evaluation of childhood abuse and neglect among Nigerian adolescents. Objective: To evaluate the Childhood Trauma Questionnaire-Short Form (CTQ-SF) in terms of its factor structure, validity, reliability, and gender measurement invariance among Nigerian adolescents. Method: Senior high school adolescents (n = 1337, aged 13-18 years) completed the CTQ-SF in addition to the Hospital Anxiety and Depression Scale (HADS), the 12-items General Health Questionnaire (GHQ-12), the Rosenberg Self-Esteem Scale (RSES) and the Positive and Negative Suicide Ideation Inventory (PANSI). Confirmatory factor analysis (CFA) was used to test the original (Bernstein et al., 2003) and alternative (Gerdner & Allgulander, 2009) CTQ-SF models. The fit indices of these two models tested applying CFA were compared. Concurrent validity of the CTQ-SF was examined with correlational analyses with other study measures. The internal consistencies of the CTQ-SF and its subscales were examined with the MacDonald's omega (wh) coefficients. Gender measurement invariance was evaluated with multiple-group CFA (MGCFA). Results: The alternative CTQ-SF model compared to the original model exhibited a better fit (CFI = 0.928, RMSEA = 0.046 [90 %CI: 0.043-0.050], SRMR = 0.044). The internal consistency and concurrent validity of this model were satisfactory. MGCFA provided evidence that supported the configural, metric and scalar gender measurement invariance. Conclusion: The alternative CTQ-SF exhibited satisfactory validity, reliability, and gender measurement invariance and, therefore, could be used for the evaluation and gender comparison of abuse and neglect among Nigerian adolescents.