Anti-CERS4 monoclonal antibody (DCABH-764)

Mouse anti-Human CERS4 monoclonal antibody for WB, ELISA, sELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Species Reactivity
Human
Immunogen
Recombinant fragment, corresponding to amino acids 57-139 of Human LASS4 with proprietary tag (NP_078828).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1 - 5 μg/ml; Sandwich ELISA: 10 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CERS4; ceramide synthase 4; LAG1 homolog, ceramide synthase 4 , LAG1 longevity assurance homolog 4 (S. cerevisiae) , LASS4; FLJ12089; Trh1; LAG1 homolog, ceramide synthase 4
Entrez Gene ID
UniProt ID

Product Background


Antigen Description
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner. The function about CERS4 antigen include sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity.
Pathway
Ceramide biosynthesis, organism-specific biosystem; Ceramide biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Sphingolipid de novo biosynthesis, organism-specific biosystem; Sphingolipid metabolism, organism-specific biosystem.

Citations


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References


Ebel, P; Imgrund, S; et al. Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia. BIOCHEMICAL JOURNAL 461:147-158(2014).
Keusch, JJ; Manzella, SM; et al. Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb(3) synthase, that directs the synthesis of isoglobo-glycosphingolipids. JOURNAL OF BIOLOGICAL CHEMISTRY 275:25308-25314(2000).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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