Anti-CERS4 monoclonal antibody (DCABH-764)
Mouse anti-Human CERS4 monoclonal antibody for WB, ELISA, sELISA
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Recombinant fragment, corresponding to amino acids 57-139 of Human LASS4 with proprietary tag (NP_078828).
WB: 1 - 5 μg/ml; Sandwich ELISA: 10 μg/ml;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
CERS4; ceramide synthase 4; LAG1 homolog, ceramide synthase 4 , LAG1 longevity assurance homolog 4 (S. cerevisiae) , LASS4; FLJ12089; Trh1; LAG1 homolog, ceramide synthase 4
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner. The function about CERS4 antigen include sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sphingosine N-acyltransferase activity.
Ceramide biosynthesis, organism-specific biosystem; Ceramide biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Sphingolipid de novo biosynthesis, organism-specific biosystem; Sphingolipid metabolism, organism-specific biosystem.
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Henion, TR; Zhou, DP; et al. Cloning of a mouse beta 1,3 N-acetylglucosaminyltransferase GlcNAc(beta 1,3)Gal(beta 1,4)Glc-ceramide synthase gene encoding the key regulator of lacto-series glycolipid biosynthesis. JOURNAL OF BIOLOGICAL CHEMISTRY 276:30261-30269(2001).
Cho, YH; Lee, CH; et al. Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. MOLECULAR PHARMACOLOGY 63:512-523(2003).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.