This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Pathway
Cell Cycle; Centrosome maturation; G2/M Transition; Loss of Nlp from mitotic centrosomes; Mitotic G2-G2/M phases; Recruitment of mitotic centrosome proteins and complexes; Regulation of PLK1 Activity at G2/M Transition.
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