This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Pathway
Cell Cycle; Chromosome Maintenance; Deposition of new CENPA-containing nucleosomes at the centromere; M Phase; Mitotic Anaphase; Mitotic Metaphase and Anaphase; Mitotic Prometaphase; Nucleosome assembly
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