Anti-CENPJ (aa 979-1088) polyclonal antibody

Species Reactivity

Human

Immunogen

CENPJ (NP_060921, 979 a.a. ~ 1088 a.a) partial recombinant protein with GST tag. The sequence is KYTTAARTFPDKKEREEIQTLKQQIADLREDLKRKETKWSSTHSRLRSQIQMLVRENTDL REEIKVMERFRLDAWKRAEAIESSLEVEKKDKLANTSVRFQNSQISSGTQ

Conjugate

Alternative Names

CENPJ; centromere protein J; LAP; CPAP; LIP1; BM032; MCPH6; SASS4; SCKL4; Sas-4; CENP-J; LAG-3-associated protein; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; centrosomal P4.1-associated protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene.

Pathway

Cell Cycle; Centrosome maturation; Loss of Nlp from mitotic centrosomes; Mitotic G2-G2/M phases