General Notes
This product (Catalog No. DPABH-11834) is a rabbit-derived polyclonal antibody raised against human CEACAM1, targeting the amino acid region 35–320 of the protein. It has been affinity purified by Protein A. CEACAM1, or carcinoembryonic antigen-related cell adhesion molecule 1 (also known as CD66a or biliary glycoprotein), is a transmembrane glycoprotein encoded by the CEACAM1 gene located on chromosome 19q13.2. It belongs to the carcinoembryonic antigen (CEA) subgroup of the immunoglobulin superfamily, which consists of membrane-anchored genes distinct from the secreted pregnancy-specific glycoprotein (PSG) subgroup, and shares evolutionary ancestry with neural cell adhesion molecule and alpha-1-B-glycoprotein. As a multifunctional cell adhesion molecule, CEACAM1 mediates calcium-independent homophilic and heterophilic interactions via its extracellular immunoglobulin-like domains, while its cytoplasmic tails enable inhibitory signaling that regulates immune responses, epithelial morphogenesis, insulin metabolism, and angiogenesis.
DPABH-11834 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-11834 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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