Anti-CDK16 monoclonal antibody (DCABH-7186) Knockout Validated

Rabbit anti-Human CDK16 monoclonal antibody for WB, FC

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Clone
FQS24321
Species Reactivity
Mouse, Rat, Human
Immunogen
Recombinant fragment within Human PCTAIRE1 aa 1-150. The exact sequence is proprietary.Database link: Q00536
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/1000 - 1/2000; Flow Cyt: 1/20;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
CDK16; cyclin-dependent kinase 16; PCTAIRE protein kinase 1 , PCTK1; FLJ16665; PCTAIRE; PCTAIRE1
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CDK16 (Cyclin-Dependent Kinase 16) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Signal transduction_PKA signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK15. The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.
Antigen Description
May play a role in signal transduction cascades in terminally differentiated cells. Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at Ser-336 (in vitro). Serine/threonine-protein kinase PCTAIRE-1 is an enzyme that in humans is encoded by the PCTK1 gene. The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene. The function about CDK16 antigen include ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Rorke, EA; Zhang, DS; et al. TGF-beta-mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21(WAF1) expression. EXPERIMENTAL CELL RESEARCH 259:149-157(2000).
Davis, T; Faragher, RGA; et al. Investigation of the signaling pathways involved in the proliferative life span barriers in Werner syndrome fibroblasts. STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE 1019:274-277(2004).

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