Anti-CDH4 (aa 635-734) polyclonal antibody

Species Reactivity

Human

Immunogen

CDH4 (NP_001785, 635 a.a. ~ 734 a.a) partial recombinant protein with GST tag. The sequence is AADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTD SGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGA

Conjugate

Alternative Names

CDH4; cadherin 4, type 1, R-cadherin (retinal); CAD4; RCAD; R-CAD; cadherin-4; R-cadherin; retinal cadherin; cadherin 4, type 1, preproprotein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.

Pathway

Adherens junctions interactions; Cell adhesion molecules (CAMs); Cell junction organization; Cell-cell junction organization.