Anti-CDH11 (aa 509-617) polyclonal antibody

Species Reactivity

Human

Immunogen

CDH11 (NP_001788, 509 a.a. ~ 617 a.a) partial recombinant protein with GST tag. The sequence is PIVTISADDKDDTANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLY LLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLST

Conjugate

Alternative Names

CDH11; cadherin 11, type 2, OB-cadherin (osteoblast); OB; CAD11; CDHOB; OSF-4; cadherin-11;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

Pathway

Adherens junctions interactions; Cell-Cell communication;