Anti-CDC42 (N-terminal) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

CDC42 antibody was raised against a 17 amino acid peptide near the amino terminus of human CDC42.

Conjugate

Alternative Names

CDC42; cell division cycle 42; G25K; CDC42Hs; cell division control protein 42 homolog; G25K GTP-binding protein; GTP-binding protein, 25kD; growth-regulating protein; GTP binding protein, 25kDa; small GTP binding protein CDC42; dJ224A6.1.1 (cell division

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

Pathway

AGE/RAGE pathway; Adaptive Immune System; Adherens junction; Androgen receptor signaling pathway; Axon guidance; BDNF signaling pathway; Bacterial invasion of epithelial cells; CD28 co-stimulation