Synthetic peptide corresponding to a region within C terminal amino acids 199-248 (SIILTTCIPS SGHSRHRYAL IPIPLAVITT CIVLYMNGIL KCDRKPDRTK) of Human LFA3 (NP_001138294.1).
Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Pathway
Cell adhesion molecules (CAMs); Cell surface interactions at the vascular wall; Epstein-Barr virus infection;
Citations
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