Anti-CD48 polyclonal antibody

The female reproductive tract adapts to allow the development of the fetus and several mechanisms are required to protect the fetus from the material immune response. Recent reports have involved ulerine NK cell activity in implantation failures and abortions. Here, we have analysed the role of prostasumes in the regulation of NK cell activity. prostasomes are small vesicles secreted byt he prostatic gland that contribute to sperm protection within the female reproductive tract because their immunosuppresive properties. The phenotypical analysis performed by flow cytometry revealed that prostasomes expressed high levels of CD48 and CD86 molecules but did not express MICAIB, CD80, CD112, or CD155. In conclusion, the expression of ligands for NK receptors in prostasomes may have functional relevance in the modulation of NK cell triggering.

Mast cells (MCs) and eosinophils (Eos) are the key players in the development of allergic inflammation (AI). Their cross-talk, named the Allergic Effector Unit (AEU), takes place through an array of soluble mediators and ligands/receptors interactions that enhance the functions of both the cells. One of the salient features of the AEU is the CD48/2B4 receptor/ligand binding complex. Furthermore, MCs and Eos have been demonstrated to play a role not only in AI but also in the modulation of its consequence, i.e., fibrosis/tissue remodeling, by directly influencing fibroblasts (FBs), the main target cells of these processes. In turn, FBs can regulate the survival, activity, and phenotype of both MCs and Eos. Therefore, a complex three players, MCs/Eos/FBs interaction, can take place in various stages of AI. The characterization of the soluble and physical mediated cross talk