C terminal amino acids 739-829 (IQLLELQLAT QHICHQKCKE EKCTYADKYT QTPWRRIPGG YSAPSFSPWQ GSFQGIPRTV PPHRRQTSST TAFQQPSQTH RSHPGKTNKA TT) of the Human FAM190B protein (Q9H7U1).
Conjugate
Unconjugated
Applications
Application Notes
IHC-P: 1/10 - 1/20.
Target
Alternative Names
CCSER2; coiled-coil serine-rich protein 2; Gcap14; FAM190B; KIAA1128; bA486O22.1; serine-rich coiled-coil domain-containing protein 2; protein FAM190B; protein GCAP14 homolog; family with sequence similarity 190, member B;
This gene encodes a member of the 5-3 exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants.
Citations
Publication ()
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