Hardware Based Testing of Communication Based Control for DC Microgrid
2017 IEEE 6TH INTERNATIONAL CONFERENCE ON RENEWABLE ENERGY RESEARCH AND APPLICATIONS (ICRERA)
Authors: Saleh, Mahmoud; Esa, Yusef; Mohamed, Ahmed
Abstract
This paper further describes our work presented in Industry Application Society 2016 Conference, with more details related to the control and operation of the microgrid. The DC microgrid facility was custom designed and implemented at CCNY with minimal off-the-shelf components to enable flexibility and reconfiguration capability. The design steps, requirements, and experimental results of the developed testbed were discussed. As a case study, a central controller for energy management algorithm was developed and tested under several operational scenarios. The experimental results verify the applicability of the developed testbed for validating DC microgrid controllers.
Cyclin Y Is Expressed in Platelets and Modulates Integrin Outside-in Signaling
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Authors: Kyselova, Anastasia; Siragusa, Mauro; Anthes, Julian; Solari, Fiorella Andrea; Loroch, Stefan; Zahedi, Rene P.; Walter, Ulrich; Fleming, Ingrid; Randriamboavonjy, Voahanginirina
Abstract
Diabetes is associated with platelet hyper-reactivity and enhanced risk of thrombosis development. Here we compared protein expression in platelets from healthy donors and diabetic patients to identify differentially expressed proteins and their possible function in platelet activation. Mass spectrometry analyses identified cyclin Y (CCNY) in platelets and its reduced expression in platelets from diabetic patients, a phenomenon that could be attributed to the increased activity of calpains. To determine the role of CCNY in platelets, mice globally lacking the protein were studied. CCNY-/- mice demonstrated lower numbers of circulating platelets but platelet responsiveness to thrombin and a thromboxane A(2) analogue were comparable with that of wild-type mice, as was agonist-induced alpha and dense granule secretion. CCNY-deficient platelets demonstrated enhanced adhesion to fibronectin and collagen as well as an attenuated spreading and clot retraction, indicating an alteration in "outside in" integrin signalling. This phenotype was accompanied by a significant reduction in the agonist-induced tyrosine phosphorylation of beta 3 integrin. Taken together we have shown that CCNY is present in anucleated platelets where it is involved in the regulation of integrin-mediated outside in signalling associated with thrombin stimulation.
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