Synthetic peptide: C-QGPNGSQNSSYSQS, corresponding to C terminal amino acids 270 - 283 of Human Cyclin C
Conjugate
Unconjugated
Applications
Application Notes
FuncS (Kinase assay): Use at an assay dependent dilution. ICC/IF: Use at an assay dependent dilution. IP: Use at 10μg/mg of lysate. WB: Use at a concentration of 5 - 10 μg/ml. Predicted molecular weight: 33 kDa.
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Developmental Biology; FBXW7 Mutants and NOTCH1 in Cancer; Gene Expression
Citations
Publication ()
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