Anti-CCNA1 (full length) polyclonal antibody

Name: Anti-CCNA1 (full length) polyclonal antibody
SKU: DPABH-09762
Rating: 5 (1 reviews)

Mouse anti-Human CCNA1 (full length) polyclonal antibody for WB

COA

SDS

Datasheet

Summary

Specifications

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Full length protein corresponding to Human Cyclin A1 aa 1-464. (ABM85414.1).Sequence: METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQPVESEAMHCSNPK SGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGI TRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCS VREGMAFEDVYEVDTG

Conjugate

Unconjugated

Applications

Application Notes

WB: 1 μg/ml;

Target

Alternative Names

CCNA1; cyclin A1; CT146; cyclin-A1;

Entrez Gene ID

8900

UniProt ID

P78396

Product Background

Antigen Description

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.

Pathway

AMPK signaling; Acute myeloid leukemia; C-MYB transcription factor network; Cell Cycle, Mitotic

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia

FERTILITY AND STERILITY

Authors: Haraguchi, Takahiro; Ishikawa, Tomomoto; Yamaguchi, Kohei; Fujisawa, Masato

Abstract

The CCNA1, CCNB1, CCNB2, PRM1, and PRM2 messenger RNA transcript ratios were significantly decreased in patients with spermatogenic disorders. These messenger RNA transcript ratios in patients with successful sperm retrieval were higher than in patients with failed sperm retrieval. (Fertil Steril (R) 2009;91:1424-6. (C) 2009 by American Society for Reproductive Medicine.)

8:2 Fluorotelomer alcohol causes G1 cell cycle arrest and blocks granulocytic differentiation in HL-60 cells

ENVIRONMENTAL TOXICOLOGY

Authors: Wang, Xia; Zhou, Chenqian; He, Bingnan; Kong, Baida; Wei, Lai; Wang, Rong; Lin, Jiajia; Shao, Yiyan; Zhu, Jianbo; Jin, Yuanxiang; Fu, Zhengwei

Abstract

Fluorotelomer alcohols (FTOHs) are fluorinated intermediates used in manufacturing specialty polymer and surfactants, with 8:2 FTOH the homologue of largest production. FTOHs were found to pose acute toxicity, hepatotoxicity, nephrotoxicity, developmental toxicity and endocrine-disrupting risks, whereas research regarding immunotoxicity and its underlying mechanism, especially on specific immune cells is limited. Here, we investigated the immunotoxicity of 8:2 FTOH on immature immune cells in an in vitro system. We observed that exposure of HL-60 cells, a human promyelocytic leukemic cell line, to 8:2 FTOH reduced cell viability in a dose- and time-dependent manner. In addition, 8:2 FTOH exposure caused G1 cell cycle arrest in HL-60 cells, while it showed no effect on apoptosis. Exposure to 8:2 FTOH inhibited the mRNA expression of cell cycle-related genes, including CCNA1, CCNA2, CCND1, and CCNE2. Moreover, exposure to 8:2 FTOH inhibited the mRNA expression of granulocytic differentiation-related genes of CD11b, CSF3R, PU.1, and C/EPB epsilon in HL-60 cells . Furthermore, 8:2 FTOH exhibited no effect on intracellular ROS level, while hydralazine hydrochloride (Hyd), one reactive carbonyl species (RCS) scavenger, partially blocked 8:2 FTOH-caused cytotoxicity in HL-60 cells. Overall, the results obtained in the study show that 8:2 FTOH poses immunotoxicity in immature immune cells and RCS may partially underline its mechanism.