Anti-CCDC65 monoclonal antibody (DCABH-200339) Made to order

Rabbit anti-Human CCDC65 monoclonal antibody for WB, ELISA

View other CCDC65 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CCDC65 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CCDC65; coiled-coil domain containing 65; CILD27; FAP250; NYD-SP28; coiled-coil domain-containing protein 65
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CCDC65 (Coiled-Coil Domain Containing 65) is a Protein Coding gene. Diseases associated with CCDC65 include ciliary dyskinesia, primary, 27 and kartagener syndrome. This gene encodes a sperm tail protein that is highly expressed in adult testis, spermatocytes and spermatids. The protein plays a critical role in the assembly of the nexin-dynein regulatory complex. Mutations in this gene result in primary ciliary dyskinesia.
Antigen Description
This gene encodes a sperm tail protein that is highly expressed in adult testis, spermatocytes and spermatids. The protein plays a critical role in the assembly of the nexin-dynein regulatory complex. Mutations in this gene result in primary ciliary dyskinesia. Ciliary dyskinesia, primary, 27 (CILD27) [MIM:615504]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. Note=The disease is caused by mutations affecting the gene represented in this entry. Cilia ultrastructure show normal outer dynein arms, radial spokes and central pairs, but a reduction in inner dynein arms and nexin links. In 5%-15% of cilia, microtubules are disorganized. Nasal epithelial cilia reveal a stiff, dyskinetic cilia waveform.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


ROUSSELLE, P; GOLBIK, R; et al. STRUCTURAL REQUIREMENT FOR CELL-ADHESION TO KALININ (LAMININ-5). JOURNAL OF BIOLOGICAL CHEMISTRY 270:13766-13770(1995).
Kroczek, C; Lang, C; et al. Swiprosin-1/EFhd2 Controls B Cell Receptor Signaling through the Assembly of the B Cell Receptor, Syk, and Phospholipase C gamma 2 in Membrane Rafts. JOURNAL OF IMMUNOLOGY 184:3665-3676(2010).

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