This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Galinski, MR; Corredor-Medina, C; et al. Plasmodium vivax merozoite surface protein-3 contains coiled-coil motifs in an alanine-rich central domain. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 101:131-147(1999).
ROUSSELLE, P; GOLBIK, R; et al. STRUCTURAL REQUIREMENT FOR CELL-ADHESION TO KALININ (LAMININ-5). JOURNAL OF BIOLOGICAL CHEMISTRY 270:13766-13770(1995).
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