Rabbit Anti-Human Syndetin (a.a. 337-593) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse; Rat

Immunogen

Recombinant human CCDC132 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 337-593 aa of BC152424

Conjugate

Application Notes

WB: 1:500-1:2000
IP: 0.5-4.0 μg for 1.0-3.0 mg of total protein lysate

General Notes

This product (Catalog No. DPABH-10319) is a rabbit-derived polyclonal antibody raised against human Syndetin, targeting the amino acid region 337–593 of the protein. This antibody exhibits cross-reactivity with Human Syndetin from mouse and rat. It has been affinity purified by Protein A. This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
DPABH-10319 is suitable for use in Western blot (WB) (1:500–1:2,000), IP (0.5-4.0 μg for 1.0-3.0 mg of total protein lysate) applications.
DPABH-10319 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CCDC132; EARP/GARPII complex subunit VPS50; Syndetin; Syndetin/CCDC132; VPS50

Entrez Gene ID

UniProt ID