Rabbit Anti-Human CCDC109B (a.a. 1-230) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant human CCDC109B protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1-230 aa of BC002633

Conjugate

Application Notes

WB: 1:500-1:1000

General Notes

This product (Catalog No. DPABH-08904) is a rabbit-derived polyclonal antibody raised against human CCDC109B, targeting the amino acid region 1–230 of the protein. It has been affinity purified by Protein A. MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010].
DPABH-08904 is suitable for use in Western blot (WB) (1:500–1:1,000) application.
DPABH-08904 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

CCDC109B; MCUb

Entrez Gene ID

UniProt ID