Specifications
Species Reactivity
Mouse; Rat; Sheep; Rabbit; Hamster; Dog; Human; Pig; Monkey
Immunogen
Recombinant full length protein corresponding to Human Caspase-7.
Applications
Application Notes
ICC/IF: 5 μg/ml; Flow Cyt: 1μg/106 cells; IHC-P: 5 - 10 μg/ml; WB: 1 μg/ml.
Target
Alternative Names
CASP7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis related cysteine protease; caspase-7; CMH 1; ICE LAP3; MCH3; CASP-7; Lice2 alpha/beta/gamma; caspase 7 isoform delta; apoptotic protease MCH-3; ICE-like apoptotic protease 3; cas
Product Background
Antigen Description
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp--Gly-217 bond. Overexpression promotes programmed cell death.
Pathway
Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem.
Citations
Publication ()
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COA
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